Laurie's first credited TV role was sorority sister Veronica in "Team", a 2004 episode of Medical Investigation. In 2009, she played Elsa in the pilot episode of The Cabonauts.
That same year, Joss Whedon cast Laurie in his show Dollhouse, which depicted a secret corporation that recruits troubled young people, stores their memories in a computer, wipes their minds (turning them into "dolls"), imprints them with new personalities, and rents them to wealthy people for special assignments. Her first major dramatic role, Laurie played a character named Mellie, who is later revealed to be a doll named November, as well as one of November's other imprinted personalities, and November's original identity, Madeleine.
In addition to acting Laurie dances and plays the ukulele in Uke Box Heroes, a ukulele cover band that she co-formed with her husband.
Laurie and her mother, Cathy Anne, appeared as members of the audience in the October 6, 2010 episode of The Late Late Show with Craig Ferguson, and participated in Ferguson's opening monologue during the cold open.